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compound 4a  (CEM Corporation)

 
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    CEM Corporation compound 4a
    Compound 4a, supplied by CEM Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound+4a/compound+3/pm40094219-211-3-30
    Average 90 stars, based on 1 article reviews
    compound 4a - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Activity Assay:

    Article Title: Advances in the design, discovery, and optimization of aurora kinase inhibitors as anticancer agents.
    Article Snippet: Introduction: Aurora kinases (AKs) play key roles during carcinogenesis and show a close relationship with many cellular effects including mitotic entry, spindle assembly and chromosomal alignment biorientation.. Indeed, elevated levels of AKs have been reported in several different tumor types, leading research scientists to investigate ways that we can target AKs for the purpose of developing new anticancer therapeutics.. Area covered: This review examines the design, discovery, and development of Aurora kinase inhibitors (AKIs) as anticancer agents and delineates their roles in cancer progression or development.

    Multiple Displacement Amplification:

    Article Title: Advances in the design, discovery, and optimization of aurora kinase inhibitors as anticancer agents.
    Article Snippet: Introduction: Aurora kinases (AKs) play key roles during carcinogenesis and show a close relationship with many cellular effects including mitotic entry, spindle assembly and chromosomal alignment biorientation.. Indeed, elevated levels of AKs have been reported in several different tumor types, leading research scientists to investigate ways that we can target AKs for the purpose of developing new anticancer therapeutics.. Area covered: This review examines the design, discovery, and development of Aurora kinase inhibitors (AKIs) as anticancer agents and delineates their roles in cancer progression or development.

    other:

    Article Title: 2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition
    Article Snippet: Ignoring compound 4p , all synthesized compounds possessed significant cell growth inhibitory activity, which was lower than 1 μM for compounds 4a , 4c–d , 4i–k , 4o and 4r in all cell lines. table ft1 table-wrap mode="anchored" t5 caption a7 Compound IC 50 (μM) a L1210 FM3A CEM HeLa 4a 0.24 ± 0.01 0.21 ± 0.03 0.20 ± 0.08 0.67 ± 0.40 4b 1.1 ± 0.0 0.98 ± 0.13 0.93 ± 0.08 1.4 ± 0.7 4c 0.13 ± 0.07 0.16 ± 0.01 0.16 ± 0.08 0.16 ± 0.02 4d 0.56 ± 0.38 0.72 ± 0.19 0.53 ± 0.38 0.88 ± 0.16 4e 1.1 ± 0.0 1.0 ± 0.2 0.99 ± 0.24 2.1 ± 1.1 4f 1.1 ± 0.1 0.88 ± 0.08 0.87 ± 0.18 0.87 ± 0.13 4g 6.0 ± 0.0 5.1 ± 0.5 4.6 ± 0.6 9.8 ± 5.0 4h 5.7 ± 0.1 4.6 ± 0.6 3.3 ± 1.7 5.0 ± 1.3 4i 0.15 ± 0.08 0.18 ± 0.01 0.18 ± 0.04 0.26 ± 0.10 4j 0.82 ± 0.31 0.82 ± 0.23 0.76 ± 0.38 0.78 ± 0.06 4k 0.27 ± 0.03 0.25 ± 0.04 0.23 ± 0.10 0.84 ± 0.10 4l 1.2 ± 0.1 1.2 ± 0.1 1.1 ± 0.3 2.3 ± 1.5 4m 6.3 ± 0.0 5.7 ± 0.5 5.4 ± 1.3 4.4 ± 0.2 4n 1.1 ± 0.1 0.99 ± 0.10 0.69 ± 0.46 0.80 ± 0.06 4o 0.48 ± 0.27 0.43 ± 0.29 0.47 ± 0.35 0.89 ± 0.08 4p >250 >250 >250 162 ± 25 4q 1.2 ± 0.1 1.1 ± 0.1 0.81 ± 0.33 1.3 ± 0.2 4r 0.99 ± 0.13 0.93 ± 0.08 0.76 ± 0.21 1.0 ± 0.3 CA-4 (nM) 3 ± 1 42 ± 6 2 ± 1 2 ± 1 Open in a separate window a IC 50 = compound concentration required to inhibit tumor cell proliferation by 50%.

    Article Title: Stochastic entropy QSAR for the in silico discovery of anticancer compounds: prediction, synthesis, and in vitro assay of new purine carbanucleosides.
    Article Snippet: AMarkov model based QSAR is introduced for the rational selection of anticancer compounds.. The model discriminates 90.3% of 226 structurally heterogeneous anticancer/non-anticancer compounds in training series.. External validation series were used to validate the model; the 91.8% containing 85 compounds, not considered to fit the model, were correctly classified.



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    Image Search Results


    In vitro anti-RSV activity.

    Journal: Viruses

    Article Title: Interaction Between the Matrix Protein and the Polymerase Complex of Respiratory Syncytial Virus

    doi: 10.3390/v16121881

    Figure Lengend Snippet: In vitro anti-RSV activity.

    Article Snippet: PC786 [ ], PC751 (compound 4a in [ ]), and AZ-27 [ ] compounds were synthesised by Sygnature Discovery Ltd. (Nottingham, UK; with final purities >98%).

    Techniques: In Vitro, Activity Assay

    Changes in viral load in vehicle, PC786- and PC751-treated ALI-cultured bronchial epithelium post RSV (0.002 MOI) apical inoculation. PC786 or PC751 was added to the apical surface, once daily from Day 0 (1 h after virus inoculation) to Day 6. The assay was conducted in triplicate, and the graph indicates geometric mean with 95% CI.

    Journal: Viruses

    Article Title: Interaction Between the Matrix Protein and the Polymerase Complex of Respiratory Syncytial Virus

    doi: 10.3390/v16121881

    Figure Lengend Snippet: Changes in viral load in vehicle, PC786- and PC751-treated ALI-cultured bronchial epithelium post RSV (0.002 MOI) apical inoculation. PC786 or PC751 was added to the apical surface, once daily from Day 0 (1 h after virus inoculation) to Day 6. The assay was conducted in triplicate, and the graph indicates geometric mean with 95% CI.

    Article Snippet: PC786 [ ], PC751 (compound 4a in [ ]), and AZ-27 [ ] compounds were synthesised by Sygnature Discovery Ltd. (Nottingham, UK; with final purities >98%).

    Techniques: Cell Culture, Virus

    SNP genotype analysis of the L-gene of RSV A2 treated with PC786 ( A ), PC751 ( B ) or wild-type RSV A2 (passage 6), and also of the M-gene of RSV A2 treated with PC786 ( C ). The axes show the relative fluorescence of the probes specific to either the WT or mutant sequence of the L-gene or M-gene.

    Journal: Viruses

    Article Title: Interaction Between the Matrix Protein and the Polymerase Complex of Respiratory Syncytial Virus

    doi: 10.3390/v16121881

    Figure Lengend Snippet: SNP genotype analysis of the L-gene of RSV A2 treated with PC786 ( A ), PC751 ( B ) or wild-type RSV A2 (passage 6), and also of the M-gene of RSV A2 treated with PC786 ( C ). The axes show the relative fluorescence of the probes specific to either the WT or mutant sequence of the L-gene or M-gene.

    Article Snippet: PC786 [ ], PC751 (compound 4a in [ ]), and AZ-27 [ ] compounds were synthesised by Sygnature Discovery Ltd. (Nottingham, UK; with final purities >98%).

    Techniques: Fluorescence, Mutagenesis, Sequencing

    PC786 treatment results in increased nuclear retention of GFP-M. Cells transfected to express GFP-Mwt were treated with 100 nM PC751 or PC786, DMSO (vehicle), or left untreated (NT) for 12 h before imaging live at 24 h post transfection. Fn/c for M protein was calculated using the formula Fn/c = (Fn − Fb)/(Fc − Fb), where Fn = nuclear fluorescence, Fc = cytoplasmic fluorescence, Fb = background autofluorescence. Unpaired Student’s t test was used to determine statistical differences indicated on the graphs. Statistical significance was set at p < 0.05. **— p < 0.001, ***— p < 0.0001, ****— p < 0.00001, ns—non significant.

    Journal: Viruses

    Article Title: Interaction Between the Matrix Protein and the Polymerase Complex of Respiratory Syncytial Virus

    doi: 10.3390/v16121881

    Figure Lengend Snippet: PC786 treatment results in increased nuclear retention of GFP-M. Cells transfected to express GFP-Mwt were treated with 100 nM PC751 or PC786, DMSO (vehicle), or left untreated (NT) for 12 h before imaging live at 24 h post transfection. Fn/c for M protein was calculated using the formula Fn/c = (Fn − Fb)/(Fc − Fb), where Fn = nuclear fluorescence, Fc = cytoplasmic fluorescence, Fb = background autofluorescence. Unpaired Student’s t test was used to determine statistical differences indicated on the graphs. Statistical significance was set at p < 0.05. **— p < 0.001, ***— p < 0.0001, ****— p < 0.00001, ns—non significant.

    Article Snippet: PC786 [ ], PC751 (compound 4a in [ ]), and AZ-27 [ ] compounds were synthesised by Sygnature Discovery Ltd. (Nottingham, UK; with final purities >98%).

    Techniques: Transfection, Imaging, Fluorescence